Marvel’s Deadpool VR, announced at Summer Game Fest 2025, features Neil Patrick Harris as the voice of Deadpool, replacing Ryan Reynolds in the gaming adaptation. Reynolds responded with a hilarious Doogie Howser parody, typing out a faux journal entry lamenting the casting change. The game, developed for Meta Quest 3 and 3S, follows Deadpool navigating Mojoworld, battling villains, and breaking the fourth wall. While some fans were surprised by Reynolds’ absence, Harris’s quick wit and comedic timing make him a strong fit for the role. Reynolds’ parody ensures he remains part of the conversation, proving his marketing genius once again.


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